In order to study the sensitivity of the ice-induced vibration response of vertical leg offshore platform to sea ice parameters, by considering the occurrence probability of sea ice parameter values, a three-factor-five-level orthogonal simulation scheme was designed. According to the ice load power spectrum density function, the simple harmonic superposition method was used to generate the ice load time history data, and the SACS software was used to build the model to calculate the structural dynamic response, and carry out range analysis, variance analysis and correlation analysis. The results show that the sensitivity of iceinduced vibration response to sea ice drift velocity is negligible, and the sensitivity to sea ice strength and ice sheet thickness is higher; and the sensitivity to sea ice strength is lower than the sensitivity to ice sheet thickness. The influence of ice thickness on the maximum base shear force is maximum, and the influence on the maximum overturning moment is minimum; the influence of strength on the maximum overturning moment is maximum, and the influence on the acceleration of the top layer is minimum. The results can provide some reference for the design of offshore platform in ice area.