In order to study the impact of passengers' reentry behavior and response time on the evacuation process of large cruise ships, an evacuation model of large cruise ships was established by using the AnyLogic simulation platform based on the social force model, and the impact of reentry behavior under different reentry proportions on the evacuation time, evacuation flow rate, crowded area and congestion duration of cruise passengers was analyzed, On this basis, the impact of passenger response time on the cruise evacuation process was considered. The simulation results show that the reentry behavior of passengers can significantly slow down the evacuation process of cruise ships and increase the congestion duration of stairs. The impact of passengers' response time on the cruise evacuation process was more complex. When the reentry ratio was 20% or less, the existence of response time slowed down the cruise evacuation process; When the reentry ratio was 30% or more, the existence of response time sped up the cruise evacuation process to a certain extent. This study has certain guiding significance for the formulation and optimization of the evacuation plan of large cruise ships.